The overall goal of the Oceans and Human Health Center on Climate Change Interactions (OHHC2I), Environmental Chemistry Project is to develop a climatically sensitive model of the production, fate and sedimentary burial of harmful algal bloom toxins in the context of microbial quorum sensing.  During the first phase of our project we will concentrate on a combinatorial, statistically robust multifactorial experimental design strategy for measuring climate change effects as expressed in changes in water quality parameters, including salinity, temperature, pH and nutrients.  Experiments will be carried out to determine single factor and multifactor (i.e. interactive) effects on the measured outcomes, which can be used to enhance HAB forecast model development.