A recent study led by Dr. Pamela Bailey, an Assistant Professor of Medicine in the School of Medicine Columbia's Department of Internal Medicine and an infectious diseases specialist at Prisma Health, has found that the antibiotic cefoxitin is as effective as traditional antimicrobial therapies for treating intra-amniotic infections and endometritis. This retrospective study compared patient outcomes within a large healthcare system between those treated with cefoxitin and those receiving standard antibiotic combinations, such as ampicillin and gentamicin. The findings revealed that cefoxitin monotherapy was noninferior to these traditional regimens, with no increase in serious clinical events like intensive care unit admissions or hospital readmissions. These results suggest that cefoxitin offers a simpler and potentially safer alternative for managing pregnancy-related infections, which could lead to updates in clinical treatment guidelines.

Read more about this study here:

Cefoxitin for Intra-amniotic Infections and Endometritis: A Retrospective Comparison to Traditional Antimicrobial Therapy Regimens Within a Healthcare System.  Bailey P, Schacht L, Pazienza G, Kohn J, Yunusa I, Seal P, Crockett A, Justo JA. Clin Infect Dis. 2024 Jul 19;79(1):247-254. doi: 10.1093/cid/ciae042.PMID: 38297884